The term ‘Prodrug’ or ‘Proagent’ was first introduced by Albert (1958) [1] to describe any compound that undergoes biotransformation prior to the exhibition of its pharmacological effect. The term ‘Prodrug’ signifies a pharmacologically inactive chemical derivative that could be used to alter the physicochemical properties of drugs in a temporary manner to increase their usefulness and/or to decrease associated toxicity.

Frustration tolerance comes under normal cognitive development. It occurs when a person while pursuing his goals cannot achieve it due to some internal or external factors. In sporting sense when injury occurs to a sportspersons, he can get frustrated.